Heritability of transforming growth factor-beta 1 and tumor necrosis factor-receptor type 1 expression and vitamin D Levels in healthy adolescent twins

Mills, Natalie T., Wright, Margie J., Henders, Anjali K., Eyles, Darryl W., Baune, Bernhard T., McGrath, John J., Byrne, Enda M., Hansell, Narelle K., Birosova, Eva, Scott, James G., Martin, Nicholas G., Montgomery, Grant W., Wray, Naomi R., and Vinkhuyzen, Anna A. E. (2015) Heritability of transforming growth factor-beta 1 and tumor necrosis factor-receptor type 1 expression and vitamin D Levels in healthy adolescent twins. Twin Research and Human Genetics, 18 (1). pp. 28-35.

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Abstract

Cytokines and vitamin D both have a role in modulating the immune system, and are also potentially useful biomarkers in mental illnesses such as major depressive disorder (MDD) and schizophrenia. Studying the variability of cytokines and vitamin D in a healthy population sample may add to understanding the association between these biomarkers and mental illness. To assess genetic and environmental contributions to variation in circulating levels of cytokines and vitamin D (25-hydroxy vitamin D: 25(OH)D3), we analyzed data from a healthy adolescent twin cohort (mean age 16.2 years; standard deviation 0.25). Plasma cytokine measures were available for 400 individuals (85 MZ, 115 DZ pairs), dried blood spot sample vitamin D measures were available for 378 individuals (70 MZ, 118 DZ pairs). Heritability estimates were moderate but significant for the cytokines transforming growth factor-beta 1 (TGF-beta 1), 0.57 (95% CI 0.26-0.80) and tumor necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63) respectively. Measures of 25(OH) D3 were within normal range and heritability was estimated to be high (0.86, 95% CI 0.61-0.94). Assays of other cytokines did not generate meaningful results. These potential biomarkers may be useful in mental illness, with further research warranted in larger sample sizes. They may be particularly important in adolescents with mental illness where diagnostic uncertainty poses a significant clinical challenge.

Item ID: 41746
Item Type: Article (Refereed Research - C1)
Keywords: cytokines, vitamin D, major depression, psychosis, heritability
ISSN: 1839-2628
Funders: Rotary Mental Health, Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC).
Projects and Grants: ARC A7960034, ARC A79906588, ARC A79801419, ARC DP0212016, ARC DP0343921 , NHMRC 389891 , NHMRC 1049911, NHMRC1069141
Date Deposited: 08 Dec 2015 16:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110311 Medical Genetics (excl Cancer Genetics) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920110 Inherited Diseases (incl. Gene Therapy) @ 100%
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