Leprosy trends in Tocantins, a hyperendemic State in the North of Brazil, 2001-2012/Tendências da hanseníase no Tocantins, um estado hiperendêmico do Norte do Brasil, 2001-2012

Monteiro, Lorena Dias, Martins-Melo, Francisco Rogerlândio, Brito, Aline Lima, Lima, Mauricélia de Silveira, Alencar, Carlos Henrique, and Heukelbach, Jorg (2015) Leprosy trends in Tocantins, a hyperendemic State in the North of Brazil, 2001-2012/Tendências da hanseníase no Tocantins, um estado hiperendêmico do Norte do Brasil, 2001-2012. Cadernos de Saude Publica, 31 (5). pp. 971-980.

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Abstract

Abstract (English): Leprosy is hyperendemic in the State of Tocantins, Brazil. The aim of the study was to analyze trends in leprosy indicators in Tocantins from 2001 to 2012, based on analysis of data from the Information System for Notifiable Diseases (SINAN), including incident cases living in Tocantins. The study calculated leprosy indicators and analyzed time trends using polynomial regression. There was a significant downward trend in overall case detection (R-2 = 0.40; p < 0.05) and proportion of paucibacillary cases (R-2 = 0.81). Detection rates remained stable in individuals < 15 years (R-2 = 0.48; p > 0.05) and cases with grade 2 physical disability (R-2 = 0.37; p > 0.05), as did the proportion of grade 2 cases (R-2 = 0.49; p > 0.05). There were significant increases in the proportions of cases with grade 1 disability (R-2 = 0.82; p < 0.05) and multibacillary cases (R-2 = 0.81; p < 0.05). Tocantins has regions with high transmission and late diagnosis of leprosy, indicating heterogeneous dissemination of the disease in the time trend analysis.

Abstract (Portugese): A hanseníase é hiperendêmica no Estado do Tocantins, Brasil. O objetivo do estudo foi analisar as tendências dos indicadores da hanseníase no Tocantins em 2001-2012. Análise de dados advindos do Sistema de Informação de Agravos de Notificação (SINAN). Incluíram-se casos novos de residentes no Tocantins. Calcularam-se os indicadores da hanseníase e analisaram-se as tendências temporais por meio de regressão polinomial. Houve tendência significativa e decrescente para a detecção geral (R2 = 0,40; p < 0,05) e proporção de casos paucibacilares (R2 = 0,81). Foi estável a detecção em < 15 anos (R2 = 0,48; p > 0,05), detecção de casos com grau 2 de incapacidade física (R2 = 0,37; p > 0,05) e proporção de casos com grau 2 (R2 = 0,49; p > 0,05). Houve aumento significativo para a proporção de casos com grau 1 de incapacidade (R2 = 0,82; p < 0,05) e proporção de casos multibacilares (R2 = 0,81; p < 0,05). O Tocantins apresenta regiões com alta transmissão e diagnóstico tardio da hanseníase, apontando a expansão da doença de forma heterogênea na análise temporal.

Item ID: 41744
Item Type: Article (Research - C1)
ISSN: 1678-4464
Keywords: leprosy, neglected diseases, endemic diseases
Additional Information:

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Date Deposited: 08 Dec 2015 18:35
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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