Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Emeto, Theophilus I., Moxon, Joseph V., Au, Minnie, and Golledge, Jonathan (2016) Oxidative stress and abdominal aortic aneurysm: potential treatment targets. Clinical Science, 130 (5). pp. 301-315.

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DOI: 10.1042/CS20150547

View at Publisher Website: http://dx.doi.org/10.1042/CS20150547

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Abstract

Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.


Item ID:	41495
Item Type:	Article (Research - C1)
ISSN:	1470-8736
Keywords:	abdominal aortic aneurysm, animal models, clinical trial, oxidative stress, pharmacotherapy
Funders:	National Health and Medical Research Council (NHMRC), Practitioner Fellowship (PF), Centre Of Research Excellence (CRE), Queensland Government (QG), Townsville Hospital Private Practice Trust Fund (THPPTF)
Projects and Grants:	NHMRC 1063476, NHMRC 1022752, NHMRC 1021416, NHMRC 1020955, NHMRC 1003707, PF 1019921, CRE 1000967
Date Deposited:	11 Mar 2016 03:54
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 60% 42 HEALTH SCIENCES > 4203 Health services and systems > 420301 Aged health care @ 40%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 60% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 20% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 20%
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