Harnessing immune responses against Plasmodium for rational vaccine design
Douradinha, Bruno, and Doolan, Denise L. (2011) Harnessing immune responses against Plasmodium for rational vaccine design. Trends in Parasitology, 27 (6). pp. 274-283.
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Abstract
In recent years, groundbreaking advances have been made in understanding the biology of and immune mechanisms against the Plasmodium spp. parasite, the causative agent of malaria. Novel features of the Plasmodium life cycle have been unravelled and immune mechanisms, which take place during both infection and immunization, have been dissected. We have undoubtedly enhanced our knowledge, but the question now is how to use this information to manipulate immune responses against Plasmodium and to develop an efficacious malaria vaccine. In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.
| Item ID: | 41443 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1471-5007 |
| Funders: | National Health and Medical Research Council (NHMRC) Australia, National Institutes of Health (NIH), USA, Pfizer Australia Senior Research Fellowship (PASRF) |
| Date Deposited: | 23 Mar 2016 02:26 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100% |
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