Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia

Kraeuter, Ann Katrin, Loxton, Heather, Costa Lima, Bruna, Rudd, Donna, and Sarnyai, Zoltán (2015) Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia. Schizophrenia Research, 169. pp. 491-493.

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Abstract

[Extract] Recent transcriptomic, proteomic and metabolomics studies suggest that abnormal glucose and energy metabolism may underlie the pathophysiology of schizophrenia (Harris et al., 2013). We hypothesized that interventions that influence energy metabolism might be therapeutically beneficial. One such intervention is the high-fat/low-carbohydrate ketogenic diet (KD) that has been effectively used in drug-resistant epilepsies (Paoli et al., 2013). To test our hypothesis we fed mice with KD for 3 weeks and induced acute NMDA receptor hypofunction by MK-801 (dizocilpine) administration to model the hypo-glutamatergic state that has been hypothesized to contribute to schizophrenia (Amann et al., 2010). We measured psychomotor hyperactivity and stereotyped behavior, social withdrawal and working memory deficits, reflecting the positive, negative and cognitive symptoms of schizophrenia, respectively (Jones et al., 2011).

Item ID: 41285
Item Type: Article (Refereed Research - C1)
ISSN: 1573-2509
Date Deposited: 17 Nov 2015 01:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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