Tumor Necrosis Factor alpha in the maintenance of hippocampal morphology and development of hippocampal-dependent cognitive tasks

Camara, M., Anscomb, H.L., and Baune, B.T. (2011) Tumor Necrosis Factor alpha in the maintenance of hippocampal morphology and development of hippocampal-dependent cognitive tasks. In: [Presented at the 41st Australasian Society for Immunology Annual Meeting]. From: 41st Australasian Society for Immunology Annual Meeting, 11-15 December 2011, Adelaide, SA, Australia.

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Abstract

[Extract] Tumor necrosis factor (TNF) is an effector cytokine involved in numerous pathologies and inflammatory responses. The source of TNF in the CNS is mainly astrocytes and microglia. In addition to its inflammatory function TNF is required for hippocampal development and development of hippocampal dependent cognitive tasks (memory and learning).

Work by this group has demonstrated that deficiency of TNF (TNF-/- mice) resulted in cognitive dysfunction of spatial memory and learning, measured by the Barnes maze, during early stages of development (3 month old mice).

Item ID: 41003
Item Type: Conference Item (Poster)
Date Deposited: 21 Nov 2016 01:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 30%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920112 Neurodegenerative Disorders Related to Ageing @ 70%
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