Signalling effects of TNF-α and its receptors in mood-like behaviour

Camara, M., Jaehne, E.J., Corrigan, F., Anscomb, H., and Baune, B.T. (2014) Signalling effects of TNF-α and its receptors in mood-like behaviour. In: Abstracts from the 2014 Meeting of the Australasian Neuroscience Society. ORAL-09-05. From: 2014 Meeting of the Australasian Neuroscience Society, 28-31 January 2014, Adelaide, SA, Australia.

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TNF-α is shown to be essential for cognitive development and plays a role in anxiety-like behaviour, partially through modulating neurotrophin expression. While we have previously shown that in young mice (3 month old) lack of TNF-α and its receptors did not affect exploratory or depression-like behaviour, it is unclear whether this role changes with ageing. This study was therefore carried out to study the effects of lack of TNF-α and its receptors on mood-like behaviours and neurotrophin expression in older mice. 6 month old TNF-KO, TNF-R1 KO and TNF-R2 KO and wild-type (WT) control mice were tested (n=14 per strain) for exploratory behaviour (Hole board exploration test, HBE) and depression-like behaviour (forced swim test, FST). Levels of NGF expression in hippocampal tissue were also measured (ELISA). TNF-KO (P < 0.05) and TNF-R1 KO (P < 0.01) mice showed impaired exploration compared to age matched WT mice. Interestingly TNF-KO and TNF-R2 KO mice had significantly lower immobility in the FST than WT mice (P < 0.001), indicating lower depression-like behaviour in these mice. However ELISA data showed no differences in NGF expression. It appears that signalling of TNF-α and TNF-R1 is important for maintaining normal exploratory behaviour in older mice. Furthermore lack of TNF-α and TNF-R2 in older mice appears protective against depression-like behaviour. This may be caused either by enhanced signalling of TNF-R1 in the TNF-R2 KO mice, or by chronic activation of TNF-α through TNF-R2 binding, but more work is needed to validate this.

Item ID: 40989
Item Type: Conference Item (Presentation)
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Date Deposited: 21 Nov 2016 01:47
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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