The role of central corticoliberin in the ether stress-induced secretion of neurohypophyseal hormones and corticosterone in the rat

Laczi, F., Iványi, T., Sarnyai, Z., Vecsernyés, M., Lengyel, G., Szabo, G., Bíró, E., Gardi, J., Julesz, J., and Telegdy, G. (1994) The role of central corticoliberin in the ether stress-induced secretion of neurohypophyseal hormones and corticosterone in the rat. Neuropeptides, 26 (1). pp. 33-37.

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Abstract

As corticotropin-releasing factor (CRF) and oxytocin (OXT) are released in response to various stressors and a role of CRF in stress-induced OXT secretion has been proposed by previous authors, the present experiments were scheduled to investigate the participation of the brain CRF system in the stress-evoked release of OXT, arginine-8-vasopressin (AVP) and corticosterone. CRF-antiserum (AS) was given into the lateral ventricle of the brain of Wistar male rats, and 24 h later, the injection was repeated 30 min prior to ether stress followed by decapitation in 5 min. Plasma OXT and AVP were measured by radioimmunoassay and corticosterone by fluorimetry. Ether stress increased the levels of corticosterone and OXT, but not that of AVP. CRF-AS alone did not change the secretion of these hormones. CRF-AS pretreatment blocked the corticosterone-releasing action of ether stress, whereas it exerted no influence on the stress-induced OXT secretion into the circulation. There was no effect of a combined application of CRF-AS and stress on the plasma AVP level. These results suggest that the central CRF system is involved in the ether stress-elicited corticosterone response, however CRF is unlikely to be connected with the regulation of OXT secretion under these experimental conditions.

Item ID: 40924
Item Type: Article (Refereed Research - C1)
ISSN: 1532-2785
Funders: Hungarian Foundation for Scientific Research (OTKA), Foundation for Research of the Hungarian Scientific Health Care Committee (ETT)
Projects and Grants: OTKA grant no. 1350, ETT grant no. T-92/1990
Date Deposited: 21 Sep 2016 07:27
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 80%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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