Laczi, F., Iványi, T., Sarnyai, Z., Vecsernyés, M., Lengyel, G., Szabo, G., Bíró, E., Gardi, J., Julesz, J., and Telegdy, G. (1994) The role of central corticoliberin in the ether stress-induced secretion of neurohypophyseal hormones and corticosterone in the rat. Neuropeptides, 26 (1). pp. 33-37.

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Abstract

As corticotropin-releasing factor (CRF) and oxytocin (OXT) are released in response to various stressors and a role of CRF in stress-induced OXT secretion has been proposed by previous authors, the present experiments were scheduled to investigate the participation of the brain CRF system in the stress-evoked release of OXT, arginine-8-vasopressin (AVP) and corticosterone. CRF-antiserum (AS) was given into the lateral ventricle of the brain of Wistar male rats, and 24 h later, the injection was repeated 30 min prior to ether stress followed by decapitation in 5 min. Plasma OXT and AVP were measured by radioimmunoassay and corticosterone by fluorimetry. Ether stress increased the levels of corticosterone and OXT, but not that of AVP. CRF-AS alone did not change the secretion of these hormones. CRF-AS pretreatment blocked the corticosterone-releasing action of ether stress, whereas it exerted no influence on the stress-induced OXT secretion into the circulation. There was no effect of a combined application of CRF-AS and stress on the plasma AVP level. These results suggest that the central CRF system is involved in the ether stress-elicited corticosterone response, however CRF is unlikely to be connected with the regulation of OXT secretion under these experimental conditions.

Item ID:	40924
Item Type:	Article (Research - C1)
ISSN:	1532-2785
Funders:	Hungarian Foundation for Scientific Research (OTKA), Foundation for Research of the Hungarian Scientific Health Care Committee (ETT)
Projects and Grants:	OTKA grant no. 1350, ETT grant no. T-92/1990
Date Deposited:	21 Sep 2016 07:27
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 80% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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