Oxytocin blocks the development of heroin-fentanyl cross-tolerance in mice

Kriván, Márta, Szabó, Gyula, Sarnyai, Zoltán, Kovacs, Gábor, and Telegdy, Gyula (1995) Oxytocin blocks the development of heroin-fentanyl cross-tolerance in mice. Pharmacology, Biochemistry and Behaviour, 52 (3). pp. 591-494.

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The development of cross-tolerance to an analgesic effect was observed between two mu-receptor agonists, heroin and fentanyl. Repeated treatments with heroin twice a day for 4 days resulted in a decreased nociceptive effect to fentanyl on day 5. The fentanyl dose-response line shifted to the right, and was considered to be a sign of the development of cross-tolerance. Peripheral treatment with oxytocin did not block the development of heroin-fentanyl cross-tolerance. However, intracerebroventricular administration of oxytocin blocked the development of tolerance, causing a leftward shift in the dose-response curve and supporting the assumption that oxytocin blocks the development of heroin-fentanyl cross-tolerance via CNS mechanisms.

Item ID: 40916
Item Type: Article (Research - C1)
ISSN: 1873-5177
Funders: Hungarian Ministry of Scoial Welfare (HMSW), Hungarian Foundation for Scientific Research (OTKA)
Projects and Grants: HMSW T-70/1990, OTKA T/3, 1354
Date Deposited: 22 Sep 2016 01:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology @ 10%
17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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