The use of transcriptional profiles to predict adult mosquito age under field conditions

Cook, Peter E., Hugo, Leon E., Iturbe-Ormaetxe, Iñaki, Williams, Craig R., Chenoweth, Stephen F., Ritchie, Scott A., Ryan, Peter A., Kay, Brian H., Blows, Mark W., and O'Neill, Scott L. (2006) The use of transcriptional profiles to predict adult mosquito age under field conditions. Proceedings of the National Academy of Sciences of the United States of America, 103 (48). pp. 18060-18065.

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Age is a critical determinant of an adult female mosquito's ability to transmit a range of human pathogens. Despite its central importance, relatively few methods exist with which to accurately determine chronological age of field-caught mosquitoes. This fact is a major constraint on our ability to fully understand the relative importance of vector longevity to disease transmission in different ecological contexts. It also limits our ability to evaluate novel disease control strategies that specifically target mosquito longevity. We report the development of a transcriptional profiling approach to determine age of adult female Aedes aegypti under field conditions. We demonstrate that this approach surpasses current cuticular hydrocarbon methods for both accuracy of predicted age as well as the upper limits at which age can be reliably predicted. The method is based on genes that display age-dependent expression in a range of dipteran insects and, as such, is likely to be broadly applicable to other disease vectors.

Item ID: 4084
Item Type: Article (Research - C1)
ISSN: 1091-6490
Keywords: mosquito; aging; transcriptional profiles; population structure
Date Deposited: 18 Jun 2009 01:22
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 51%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 49%
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