Suppression of inflammation by helminths: a role for the gut microbiota

Giacomin, Paul, Croese, John, Krause, Lutz, Loukas, Alex, and Cantacessi, Cinzia (2015) Suppression of inflammation by helminths: a role for the gut microbiota. Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (1675). 20140296. pp. 1-6.

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Abstract

Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host–parasite–microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation.

Item ID: 40723
Item Type: Article (Research - C1)
ISSN: 1471-2970
Keywords: helminth-induced suppression of inflammation; hookworms; host–parasite interactions; microbial richness; microbiota; whipworms
Additional Information:

© 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

Funders: Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme, Australian National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC grant no. 1037304, NHMRC grant no. 1020114, NHMRC grant no. 1052938, NHMRC grant no. 613718
Date Deposited: 11 Oct 2015 23:20
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 33%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 33%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology @ 34%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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