One base pair deletion and high rate of evolution: keys to viral accommodation of Australian Penaeus stylirostris densovirus

Jaroenram, Wansadaj, Chaivisuthangkura, Parin, and Owens, Leigh (2015) One base pair deletion and high rate of evolution: keys to viral accommodation of Australian Penaeus stylirostris densovirus. Aquaculture, 443. pp. 40-48.

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Abstract

Penaeus stylirostris densovirus (PstDV) has caused large economic losses to shrimp farming worldwide. Here, a 1-bp deletion within the nuclear localization signal-encoding sequence of open reading frame 1 (ORF1; NS1) of Australian PstDV was identified as a cause of 199-amino acid shortened NS1 protein and production of a second protein, C-terminal NS1. This mutation is believed to reduce virulence as it strongly modifies the characteristics of NS1, which is responsible for the majority of enzymatic activities in PstDV. This finding supports a hypothesis regarding accommodation of PstDV in Australian prawns in relation to viral genetics. However, a high degree of evolution (1.55 × 10^−3 substitutions/site/year) and genetic variation for the virus was attributable to the viral recombination observed with 10 potential genomic breakpoints identified. With this finding, we suggest that awareness of the emergence of new virulent strains should be increased as a preventative measure against future outbreaks of PstDV in the Australian Indo-Pacific.

Item ID: 40669
Item Type: Article (Research - C1)
ISSN: 1873-5622
Keywords: Penaeus stylirostris densovirus; viral accommodation; point mutation; viral Evolution; IHHNV
Funders: Indo-Australia Biotechnology (IAB), James Cook University
Projects and Grants: IAB Grant BF50090
Date Deposited: 01 Oct 2015 02:55
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060506 Virology @ 50%
07 AGRICULTURAL AND VETERINARY SCIENCES > 0704 Fisheries Sciences > 070404 Fish Pests and Diseases @ 50%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8301 Fisheries - Aquaculture > 830105 Aquaculture Prawns @ 100%
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