Abdominal distension and Escherichia coli peritonitis in mice lacking myeloid differentiation factor 88

Johnson, Linda K., Widi, Antin Y.N., Rowarth, Serrin, and Baxter, Alan G. (2015) Abdominal distension and Escherichia coli peritonitis in mice lacking myeloid differentiation factor 88. Comparative medicine, 65 (2). pp. 123-126.

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Abstract

Here we describe the gross and microscopic findings of naturally occurring, β-hemolytic Escherichia coli peritonitis in B6.129-Myd88^tm1Aki male and female mice. Over approximately 5 mo, 10 homozygous mutant mice deficient in myeloid differentiation factor 88 (C57BL/6 strain; male and female) that had not been used in research protocols developed rapid-onset abdominal swelling associated with copious viscous ascites. Each mouse developed an anterior peritonitis, primarily involving the parietal peritoneum and the visceral surface of the spleen, liver, diaphragm, and stomach. Inflammation was confined to the organ surfaces, with no indication of septicemia or grossly apparent gastrointestinal perforation or other tissue compromise that would initiate peritonitis. Peritonitis was likely attributable to compromised antibacterial innate immunity; cohoused, similarly immunodeficient littermates did not develop similar clinical signs. An unusual finding in all cases was mesothelial cell hyperplasia and hypertrophy. Although the underlying innate immune deficiency accounts for much of the observed pathology, the remarkable mesothelial cell morphology and the episodic nature of the peritonitis in some littermates and not others remain unexplained.

Item ID: 40635
Item Type: Article (Refereed Research - C1)
Keywords: MyD88, myeloid differentiation response 88; TLR, Toll-like receptor
ISSN: 1532-0820
Date Deposited: 28 Oct 2015 22:59
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110706 Immunogenetics (incl Genetic Immunology) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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