Advancement in calciphylaxis management: report of 3 cases
Edwards, Harrison A., and Barnes, Chadwick E. (2015) Advancement in calciphylaxis management: report of 3 cases. In: Posters from the 48th Annual Scientific Meeting of the Australasian College of Dermatologists . From: 48th Annual Scientific Meeting of the Australasian College of Dermatologists , 16-19 May 2015, Adelaide, SA, Australia.
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Abstract
Classically, calciphylaxis (calcific uraemic arteriolopathy – CUA) has been considered a disease of patients with advanced or end-stage renal disease. However, calciphylaxis in patients without an incriminating history or renal function is not as rare as previously believed; thus patients may present to dermatology after referral from primary care.
Calciphylaxis involves life-threatening calcification of arterioles leading to necrotic infarcts of the skin and subcutaneous tissue (panniculus adiposus), erythema and livedo reticularis, followed by painful, pre-ulcerative, subcutaneous plaques with surrounding pruritic areas. These areas ulcerate revealing regions of necrotic subcutaneous adipose tissue covered by eschars with high potential for infectious complication.
The incidence of calciphylaxis is approximately 4.1% in patients on dialysis, with the reported incidence increasing over the past decade. It is associated with significant morbidity and mortality, with limited studies suggesting a one-year cause-specific mortality of 54.2%.
The rapid progression of calciphylaxis lesions highlights the need for swift response when the early signs we describe appear. It is our experience that quicker diagnosis and increasing familiarity and expertise has simplified and improved the course of recovery for these patients. Optimally, calciphylaxis is prevented. Therefore, the diagnostician must maintain a high degree of suspicion for patients with the risk factors we describe. Ongoing research and accumulating experience will be needed to improve outcomes of this devastating condition.
Multi-country, cross-sectional study to determine patient-specific and general beliefs toward medication and their treatment adherence to selected systemic therapies in 6 chronic immune-mediated inflammatory diseases (ALIGN)
| Item ID: | 40579 |
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| Item Type: | Conference Item (Poster) |
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| Additional Information: | A published abstract is also available from the Related URLs link below and can be cited as: Edwards, H.A., Barnes, C.E. (2015) Advancement in calciphylaxis management: report of 3 cases. Australasian Journal of Dermatology, 56 (S2). pp. S169. |
| Date Deposited: | 18 Sep 2015 03:01 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110304 Dermatology @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110312 Nephrology and Urology @ 50% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920117 Skin and Related Disorders @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920119 Urogenital System and Disorders @ 50% |
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