Associations among smoking status, lifestyle and lipoprotein subclasses

Beauchamp, Alison, Tonkin, Andrew, Peeters, Anna, Wolfe, Rory, Turrell, Gavin, Harriss, Linton, Giles, Graham G., English, Dallas R., and Jenkins, Alicia J. (2010) Associations among smoking status, lifestyle and lipoprotein subclasses. Journal of Clinical Lipidology, 4 (6). pp. 522-530.

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The relationship between cigarette smoking and cardiovascular disease is well established, yet the underlying mechanisms remain unclear. Although smokers have a more atherogenic lipid profile, this may be mediated by other lifestyle-related factors. Analysis of lipoprotein subclasses by the use of nuclear magnetic resonance spectroscopy (NMR) may improve characterisation of lipoprotein abnormalities.


We used NMR spectroscopy to investigate the relationships between smoking status, lifestyle-related risk factors, and lipoproteins in a contemporary cohort.


A total of 612 participants (360 women) aged 40–69 years at baseline (1990−1994) enrolled in the Melbourne Collaborative Cohort Study had plasma lipoproteins measured with NMR. Data were analysed separately by sex.


After adjusting for lifestyle-related risk factors, including alcohol and dietary intake, physical activity, and weight, mean total low-density lipoprotein (LDL) particle concentration was greater for female smokers than nonsmokers. Both medium- and small-LDL particle concentrations contributed to this difference. Total high-density lipoprotein (HDL) and large-HDL particle concentrations were lower for female smokers than nonsmokers. The proportion with low HDL particle number was greater for female smokers than nonsmokers. For men, there were few smoking-related differences in lipoprotein measures.


Female smokers have a more atherogenic lipoprotein profile than nonsmokers. This difference is independent of other lifestyle-related risk factors. Lipoprotein profiles did not differ greatly between male smokers and nonsmokers.

Item ID: 40471
Item Type: Article (Research - C1)
ISSN: 1876-4789
Keywords: atherosclerosis; lifestyle; lipoproteins; smoking; spectroscopy
Funders: Victorian Health Promotion Unit (VicHealth), The Cancer Council Victoria, National Health and Medical Research Council (NHMRC), Monash University
Projects and Grants: NHMRC ID No. 209057, NHMRC ID No. 334032, NHMRC ID 465352, NHMRC ID 390109
Date Deposited: 16 Sep 2015 03:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920401 Behaviour and Health @ 50%
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