Biomarker of early glomerular injury in pre-eclampsia

Kandasamy, Yogavijayan, Watson, David, and Rudd, Donna (2015) Biomarker of early glomerular injury in pre-eclampsia. Hypertension in Pregnancy, 34 (4). pp. 391-399.

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Objectives: Nephrin is an integral part of podocytes that together with endothelial cells and the basement form the glomerular filtration barrier. Placental ischemia triggers a cascade of events that ultimately result in endothelial malfunction, hypertension, podocytopathy and fetal compromise. Methods: We review the literature to determine if urine nephrin measurements could serve as a useful biomarker to detect early podocyte injury in pre-eclampsia. Results: Our search identifies eight studies published to date. The findings of these studies demonstrate that urine nephrin excretion plays a critical role in the pathogenesis of proteinuria during pre-eclampsia and that this is a good indicator of glomerular injury. Conclusion: There is thus an urgent need for a large multi-centre clinical study using standardized recruitment criteria to determine the full potential of this biomarker in clinical practice.

Item ID: 40468
Item Type: Article (Research - C1)
ISSN: 1525-6065
Keywords: nephrin, pre-eclampsia, podocytopathy, glomerular injury, hypertension
Date Deposited: 18 Nov 2015 00:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111402 Obstetrics and Gynaecology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110302 Clinical Chemistry (diagnostics) @ 50%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920507 Womens Health @ 20%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920114 Reproductive System and Disorders @ 30%
92 HEALTH > 9202 Health and Support Services > 920203 Diagnostic Methods @ 50%
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