Harriss, Linton R., English, Dallas R., Hopper, John L., Powles, John, Simpson, Julie A., O'Dea, Kerin, Giles, Graham G., and Tonkin, Andrew M. (2007) Alcohol consumption and cardiovascular mortality accounting for possible misclassification of intake: 11-year follow-up of the Melbourne Collaborative Cohort Study. Addiction, 102 (10). pp. 1574-1585.

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Abstract

Aims: To investigate the relationship between usual daily alcohol intake, beverage type and drinking frequency on cardiovascular (CVD) and coronary heart disease (CHD) mortality, accounting for systematic misclassification of intake. Design Prospective cohort study with mean follow-up of 11.4 years. Setting The Melbourne Collaborative Cohort Study, Australia. Participants A total of 38 200 volunteers (23 044 women) aged 40–69 years at baseline (1990–1994). Measurements Self-reported alcohol intake using beverage-specific quantity–frequency questions (usual intake) and drinking diary for previous week. Findings Compared with life-time abstention, usual daily alcohol intake was associated with lower CVD and CHD mortality risk for women but not men. For women, the hazard ratio [HR (95% CI)] for CVD for those drinking > 20 g/day alcohol was 0.43 (0.19–0.95; P trend = 0.18), and for CHD, 0.19 (0.05–0.82; P trend = 0.24). Male former drinkers had over twice the mortality risk for CVD [HR = 2.58 (1.51–4.41)] and CHD [HR = 2.91 (1.59–5.33)]. Wine was the only beverage associated inversely with mortality for women. Compared with drinkers who consumed no alcohol in the week before baseline, drinking frequency was associated inversely with CVD and CHD mortality risk for men but not women. HR for men drinking 6–7 days/week was 0.49 (0.29–0.81; P trend = 0.02) for CVD, and 0.49 (0.26–0.92: P trend = 0.23) for CHD. Conclusions Usual daily alcohol intake was associated with reduced CVD and CHD mortality for women but not men. This benefit appeared to be mainly from wine, although comparison of beverages was not possible. Drinking frequency was associated inversely with CVD and CHD death for men but not women.

Item ID:	40467
Item Type:	Article (Research - C1)
ISSN:	1360-0443
Keywords:	alcohol, alcoholic beverages, cardiovascular disease, coronary heart disease, drinking frequency, mortality, prospective cohort study
Funders:	VicHealth (VH), Cancer Council Victoria, National Health and Medical Research Council of Australia (NHMRC), Australian Brewers Foundation
Projects and Grants:	NHMRC 284476, NHMRC 209057, NHMRC 124317, NHMRC 251533, VH 2003-0759
Date Deposited:	16 Sep 2015 03:40
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 40% 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 30% 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified @ 30%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 40% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920414 Substance Abuse @ 40% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 20%
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