Kennedy, Glen A., Curnow, Jennifer L., Gooch, Julie, Williams, Bronwyn, Wood, Peter, Pitman, Catherine, McBryde, Emma, and Woods, Marion (2002) Histoplasma capsulatum in peripheral blood smears. British Journal of Haematology, 116 (3). p. 503.

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Abstract

A 39-year-old man with acquired immunodeficiency syndrome (AIDS; CD4 count 10 x 10 12 / 1) presented with weight loss, fevers and pancytopenia, with Hb 7·1 g / dl, platelet count 72 x 10 9 x l and white cell count 1·8 x 10 9 / l. A peripheral blood film revealed occasional circulating neutrophils containing intracytoplasmic oval, yeast-like organisms approximately 3 μm in length (top). Large numbers of yeast cells were present in association with mononuclear cells on buffy coat preparation (bottom), and within histiocytes and fat lobules on subsequent bone marrow trephine biopsy. Microbiological cultures of the bone marrow sample grew Histoplasma capsulatum variant capsulatum. With the institution of amphotericin B, fevers resolved and the peripheral blood count slowly recovered over the subsequent 6 weeks.

Item ID:	40430
Item Type:	Article (Case Study)
ISSN:	1365-2141
Date Deposited:	08 Oct 2015 02:24
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 40% 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 40% 16 STUDIES IN HUMAN SOCIETY > 1605 Policy and Administration > 160508 Health Policy @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50% 92 HEALTH > 9202 Health and Support Services > 920207 Health Policy Evaluation @ 50%
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