Insecticide resistance in areas under investigation by the international centers of excellence for malaria research: a challenge for malaria control and elimination

Quiñones, Martha L., Norris, Douglas E., Conn, Jan E., Moreno, Marta, Burkot, Thomas R., Bugoro, Hugo, Keven, John B., Cooper, Robert, Yan, Guiyun, Rosas, Angel, Palomino, Miriam, Donnelly, Martin J., Mawejje, Henry D., Eapen, Alex, Montgomery, Jacqui, Coulibaly, Mamadou B., Beier, John C., and Kumar, Ashwani (2015) Insecticide resistance in areas under investigation by the international centers of excellence for malaria research: a challenge for malaria control and elimination. American Journal of Tropical Medicine and Hygiene, 93 (Suppl 3). pp. 69-78.

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Abstract

Scale-up of the main vector control interventions, residual insecticides sprayed on walls or structures and/or impregnated in bed nets, together with prompt diagnosis and effective treatment, have led to a global reduction in malaria transmission. However, resistance in vectors to almost all classes of insecticides, particularly to the synthetic pyrethroids, is posing a challenge to the recent trend of declining malaria. Ten International Centers of Excellence for Malaria Research (ICEMR) located in the most malaria-endemic regions of the world are currently addressing insecticide resistance in the main vector populations, which not only threaten hope for elimination in malaria-endemic countries but also may lead to reversal where notable reductions in malaria have been documented. This communication illustrates the current status of insecticide resistance with a focus on the countries where activities are ongoing for 9 out of the 10 ICEMRs. Most of the primary malaria vectors in the ICEMR countries exhibit insecticide resistance, albeit of varying magnitude, and spanning all mechanisms of resistance. New alternatives to the insecticides currently available are still to be fully developed for deployment. Integrated vector management principles need to be better understood and encouraged, and viable insecticide resistance management strategies need to be developed and implemented.

Item ID: 40416
Item Type: Article (Research - C1)
ISSN: 1476-1645
Additional Information:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Date Deposited: 09 Sep 2015 00:14
FoR Codes: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060808 Invertebrate Biology @ 50%
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060303 Biological Adaptation @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100%
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