Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification

Bazaka, K., Jacob, M.V., Chrzanowski, W., and Ostrikov, K. (2015) Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification. RSC Advances, 5 (60). pp. 48739-48759.

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Strategies that confine antibacterial and/or antifouling property to the surface of the implant, by modifying the surface chemistry and morphology or by encapsulating the material in an antibiotic-loaded coating, are most promising as they do not alter bulk integrity of the material. Among them, plasma-assisted modification and catechol chemistry stand out for their ability to modify a wide range of substrates. By controlling processing parameters, plasma environment can be used for surface nano structuring, chemical activation, and deposition of biologically active and passive coatings. Catechol chemistry can be used for material-independent, highly-controlled surface immobilisation of active molecules and fabrication of biodegradable drug-loaded hydrogel coatings. In this article, we comprehensively review the role plasma-assisted processing and catechol chemistry can play in combating bacterial colonisation on medically relevant coatings, and how these strategies can be coupled with the use of natural antimicrobial agents to produce synthetic antibiotic-free antibacterial surfaces.

Item ID: 40273
Item Type: Article (Research - C1)
ISSN: 2046-2069
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This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Funders: Australian Research Council (ARC)
Date Deposited: 25 Aug 2015 23:46
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091299 Materials Engineering not elsewhere classified @ 100%
SEO Codes: 85 ENERGY > 8598 Environmentally Sustainable Energy Activities > 859899 Environmentally Sustainable Energy Activities not elsewhere classified @ 100%
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