Role of angiogenesis in HCC development and therapy

Hebbard, Lionel W. (2012) Role of angiogenesis in HCC development and therapy. In: Qiao, Liang, Li, Yumin, Yan, Xiang, and George, Jacob, (eds.) Molecular Aspects of Hepatocellular Carcinoma. Bentham Books, Ipswich, QLD, Australia, pp. 149-161.

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A pre-requisite for tumour growth and metastasis is angiogenesis, the sprouting and growth of new capillaries from pre-existing blood vessels. Tumours without the ability to induce the growth of new capillaries remain small, in the order of 1-2 mm3. Drugs are now available, such as Bevacizumab, to inhibit angiogenesis and human tumour growth. Hepatocellular carcinoma (HCC) is a very aggressive human cancer, has clear angiogenic characteristics and patients with HCC have a very poor clinical outlook. In this context, we review the mechanisms of the predominant angiogenic pathways and how their targeting can impact on liver tumour growth. We also discuss the role of hepatitis in influencing liver tumour blood vessel growth. Equally, the role of the hepatic manifestation of the metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is considered, since it is now one of most common causes of liver disease in Western Societies. There are links between angiogenesis and metabolism and although poorly researched in respect of HCC, these we examine as they may impact on liver tumour formation and progression. Finally, we report on the current status of trials of anti-angiogenic HCC therapy and consider the potential limitations of such a therapeutic strategy.

Item ID: 40196
Item Type: Book Chapter (Research - B1)
ISBN: 978-1-60805-072-7
Keywords: angiogenesis, hepatocellular carcinoma, anti-angiogenic therapy
Date Deposited: 31 Aug 2015 02:49
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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