Non-viral causes of liver cancer: does obesity led inflammation play a role

Alzahrani, Badr, Iseli, Tristan J., and Hebbard, Lionel W. (2014) Non-viral causes of liver cancer: does obesity led inflammation play a role. Cancer Letters, 345 (2). pp. 223-229.

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Abstract

Liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Hepatocellular carcinoma (HCC) accounts for around 90% of primary liver cancers. Chronic infection with hepatitis B and hepatitis C viruses are two of most common causes of liver cancer. However, there are non-viral factors that are associated with liver cancer development. Numerous population studies have revealed strong links between obesity and the development of liver cancer. Obesity can alter hepatic pathology, metabolism and promote inflammation, leading to nonalcoholic fatty liver disease (NAFLD) and the progression to the more severe form, non-alcoholic steatohepatitis (NASH). NASH is characterised by prominent steatosis and inflammation, and can lead to HCC. Here, we discuss the role of obesity in inflammation and the principal signalling mechanisms involved in HCC formation.

Item ID: 40181
Item Type: Article (Research - C1)
ISSN: 1872-7980
Keywords: obesity; liver cancer; inflammation
Funders: Aljouf University, Saudi Arabia, National Health and Medical Research Council (NHMRC), Robert W. Storr Bequest to the University of Sydney
Projects and Grants: NHMRC Project Grant 632630, NHMRC Project Grant 1006200
Date Deposited: 26 Aug 2015 23:59
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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