Role of adiponectin and its receptors in cancer

Obeid, Stephanie, and Hebbard, Lionel (2012) Role of adiponectin and its receptors in cancer. Cancer biology & medicine, 9 (4). pp. 213-220.

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Abstract

Adiponectin (APN), a novel hormone/cytokine derived from adipocyte tissue, is involved in various physiological functions. Genetics, nutrition, and adiposity are factors contributing to circulating plasma concentrations of APN. Clinical correlation studies have shown that lower levels of serum APN are associated with increased malignancy of various cancers, such as breast and colon cancers, suggesting that APN has a role in tumorigenesis. APN affects insulin resistance, thus further influencing cancer development. Tumor cells may express receptors for APN. Cellular signaling is the mechanism by which APN exerts its host-protective responses. These factors suggest that serum APN levels and downstream signaling targets of APN may serve as potential diagnostic markers for malignancies. Further research is necessary to clarify the exact role of APN in cancer diagnosis and therapy.

Item ID: 40179
Item Type: Article (Research - C1)
ISSN: 2095-3941
Keywords: adiponectin, cancer, signaling
Funders: National Health and Medical Research Council (NHMRC), Cancer Council of New South Whales (CC), Robert W. Storr Bequest to the University of Sydney
Projects and Grants: NHMRC Project Grant ID1006200
Date Deposited: 27 Aug 2015 05:25
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060110 Receptors and Membrane Biology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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