Animal models of nonalcoholic fatty liver disease

Hebbard, Lionel, and George, Jacob (2011) Animal models of nonalcoholic fatty liver disease. Nature reviews. Gastroenterology & hepatology, 8. pp. 35-44.

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In 1980, Ludwig and colleagues described a series of patients with liver histology characterized by the accumulation of fat and the presence of hepatic necroinflammation in the absence of a history of excessive alcohol consumption. They coined the term nonalcoholic steatohepatitis (NASH), which today is regarded as one of the most common causes of liver disease in affluent countries. NASH is a subset of a larger spectrum of diseases termed fatty liver disease (including alcoholic and nonalcoholic fatty liver disease; AFLD and NAFLD, respectively). NAFLD and NASH are linked to visceral adiposity, insulin resistance, dyslipidemia and type 2 diabetes, and are increasing due to the prevalence of the metabolic syndrome. In this context, research has been undertaken using animals to model human steatosis and NAFLD to NASH disease progression. This Review discusses the prevalent dietary and inflammation-based genetic animal models described in recent years.

Item ID: 40175
Item Type: Article (Research - C1)
ISSN: 1759-5053
Funders: National Health and Medical Research Council (NHMRC), Robert W. Storr Bequest of the University of Sydney
Projects and Grants: NHMRC Project Grant No. 632630
Date Deposited: 30 Aug 2015 23:43
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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