Increased expression of H/T-cadherin in tumor-penetrating blood vessels

Wyder, Lorenza, Vitaliti, Alessandra, Schneider, Henriette, Hebbard, Lionel W., Moritz, Dirk R., Wittmer, Mariana, Ajmo, Malek, and Klemenz, Roman (2000) Increased expression of H/T-cadherin in tumor-penetrating blood vessels. Cancer research, 60. pp. 4682-4688.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Neovascularization is a prerequisite for tumor growth. Thus, selective destruction of the tumor vasculature should prevent tumor expansion. We have established a method to identify proteins that are specifically expressed on the surface of endothelial cells in tumors. CD31-positive endothelial cells were isolated from Lewis lung carcinoma lung metastases as well as from normal lung tissue. cDNAs derived from these cells were subjected to a subtractive hybridization procedure, and cDNAs overrepresented in tumor-derived endothelial cells were isolated; those encoding surface proteins were selected using a signal sequence trap assay. One isolated cDNA encoded H/T-cadherin. In this report, we show that mouse H/T-cadherin is overexpressed on endothelial cells of several tumors, whereas it is expressed only on a subset of endothelial cells in healthy organs. On the basis of the expression of H/T-cadherin in lung metastases of different tumors, we suggest that different tumors can have a differential influence on the expression of endothelial cell surface proteins.

Item ID: 40167
Item Type: Article (Research - C1)
ISSN: 1538-7445
Funders: Swiss National Foundation (SNF)
Projects and Grants: SNF NFP37 Grant 40-44820.95
Date Deposited: 31 Aug 2015 02:20
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060110 Receptors and Membrane Biology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page