Pharmacokinetics of a continuous rate infusion of ceftiofur sodium in normal foals

Wearn, J.M.G., Davis, J.L., Hodgson, D.R., Raffetto, J.A., and Crisman, M.V (2013) Pharmacokinetics of a continuous rate infusion of ceftiofur sodium in normal foals. Journal of veterinary pharmacology and therapeutics, 36 (1). pp. 99-101.

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[Extract] Systemic bacterial infection, resulting in bacterial sepsis and systemic inflammatory response syndrome, is the primary cause of equine neonatal morbidity and mortality (Cohen, 1994; Hollis et al., 2008). Ceftiofur sodium (CS), a third-generation cephalosporin antimicrobial, has in vitro efficacy against many bacterial organisms cultured from septicemic equine neonates (Jaglan et al., 1994; Marsh & Palmer, 2001; Sanchez et al., 2008; Meyer et al., 2009).

Ceftiofur sodium is a time-dependent, bactericidal, β-lactam antimicrobial (Owens & Ambrose, 2007). To optimize the likelihood of efficacy, dosing regimens are designed to maximize the duration concentrations of antimicrobial at the site of infection are greater than the MIC of the pathogen (Turnidge, 1998). For gram-positive organisms, CS has a period of post-antibiotic effect and post-antibiotic leukocyte enhancement. For gram-negative organisms no post-antibiotic effect exists and reduced efficacy of cephalosporin antimicrobial therapy has been reported when T > MIC is <80% (Craig, 2002). In neutropenic patients, maintaining T > MIC for 90–100% of the dosing interval is recommended (Turnidge, 1998).

Item ID: 40140
Item Type: Article (Short Note)
ISSN: 1365-2885
Funders: Virginia Horse Industry Board
Date Deposited: 28 Oct 2015 00:13
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070710 Veterinary Pharmacology @ 100%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830306 Horses @ 100%
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