Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: insights from modeling

Van Kerkhove, Maria D., Asikainen, Tommi, Becker, Niels G., Bjorge, Steven, Desenclos, Jean-Claude, dos Santos, Thais, Fraser, Christophe, Leung, Gabriel M., Lipsitch, Marc, Longini, Ira M., McBryde, Emma S., Roth, Cathy E., Shay, David K., Smith, Derek J., Wallinga, Jacco, White, Peter J., Ferguson, Neil M., and Riley, Steven (2010) Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: insights from modeling. PLoS Medicine, 7 (6). e1000275. pp. 1-6.

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The emergence and global spread of a novel strain of human influenza A/H1N1 during 2009 (pandemic [H1N1] 2009 influenza, or H1N1pdm) has highlighted the importance of data from both detailed outbreak investigations and population surveillance for the support of public health decision making. For example, public health organizations in several countries undertook detailed case investigations to build databases of the first few hundred cases, which include laboratory confirmation status, age, relative severity, exposure history, onset of symptoms, and contact history (for example, the UK First Few Hundred project [1]). Descriptive analyses of such data allowed decision-makers to conclude rapidly that the disease caused by the novel strain was relatively mild for the majority of confirmed cases and that it was being transmitted efficiently between children. Therefore, most countries decided that stringent interventions at the community level (such as proactive school closures) were not appropriate, because their benefits were limited when compared with the high overall cost to society. Population surveillance was also crucial in the early stages of the pandemic. Indeed, the two independent influenza cases [2] that provided the viral isolates used to discern the presence of a novel strain were obtained through a sentinel surveillance system designed for exactly that purpose [3].

Item ID: 39766
Item Type: Article (Research - C1)
ISSN: 1549-1676
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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

Funders: Bill and Melinda Gates Foundation, Royal Society, Medical Research Council (MRC), UK Health Protection Agency, National Institutes of Health (NIH), Wellcome Trust (WT) 3R01TW008246-01S1, Fogarty International Center, Department of Homeland Security, Institut de Veille Sanitaire Sanitaire
Projects and Grants: MRC EU FP7, NIH 1U54GM088588, NIH Director's Pioneer Award DP1-OD000490-01, WT
Date Deposited: 08 Sep 2015 03:56
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 40%
16 STUDIES IN HUMAN SOCIETY > 1605 Policy and Administration > 160508 Health Policy @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9202 Health and Support Services > 920207 Health Policy Evaluation @ 50%
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