No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus

Eisen, Damon P., Marshall, Caroline, Dean, Melinda M., Sasadeusz, Joe, Richards, Michael, Buising, Kirsty, Cheng, Allen, Johnson, Paul D.R., Barr, Ian G., and McBryde, Emma S. (2011) No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus. Human Immunology, 72 (11). pp. 1091-1094.

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DOI: 10.1016/j.humimm.2011.08.014

View at Publisher Website: http://dx.doi.org/10.1016/j.humimm.2011....

Abstract

Genetic variations in host immunity may influence susceptibility to novel infections like the recently emergent pandemic influenza virus. Prior studies demonstrated that mannose-binding lectin (MBL) inactivates influenza. Furthermore, MBL deficiency is common and appears to predispose to respiratory virus infections. Therefore, we studied whether MBL deficiency played a role in infection with the novel H1N1 2009 influenza strain in exposed health care workers. In a nested case–control study, we observed no association between phenotypic MBL deficiency, variously defined, and predisposition to H1N1 2009 influenza in 63 pairs of seropositive and seronegative participants. MBL appears to currently have little impact on innate immune responses to H1N1 2009 influenza.


Item ID:	39763
Item Type:	Article (Research - C1)
ISSN:	1879-1166
Keywords:	innate immunity; mannose-binding lectin; deficiency; influenza; pandemic
Funders:	National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants:	NHMRC Strategic Award, Urgent Research H1N1 Influenza No. 60499
Date Deposited:	02 Sep 2015 03:54
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 40% 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 40% 16 STUDIES IN HUMAN SOCIETY > 1605 Policy and Administration > 160508 Health Policy @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60% 92 HEALTH > 9203 Indigenous Health > 920309 Pacific Peoples Health - Health System Performance (incl. Effectiveness of Interventions) @ 20% 92 HEALTH > 9202 Health and Support Services > 920207 Health Policy Evaluation @ 20%
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