Miliary tuberculosis following negative latent tuberculosis infection screening prior to tumor necrosis factor-α antagonists: implications for management?
Teh, Benjamin W., Street, Alan C., McBryde, Emma S., and Denholm, Justin T. (2012) Miliary tuberculosis following negative latent tuberculosis infection screening prior to tumor necrosis factor-α antagonists: implications for management? Journal of Rheumatology, 39 (6). pp. 1297-1298.
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Abstract
[Extract] Tumor necrosis factor-α (TNF-α) antagonists are effective treatments for inflammatory disorders but are associated with an increased risk of infections including reactivation of latent tuberculosis infection (LTBI). We describe a patient who developed miliary TB as a complication of TNF-α antagonist therapy despite negative pretherapy screening for LTBI.