Low-dose aspirin and ibuprofen's sterilizing effects on mycobacterium tuberculosis suggest safe new adjuvant therapies for tuberculosis

Eisen, Damon P., McBryde, Emma S., and Walduck, Anna (2013) Low-dose aspirin and ibuprofen's sterilizing effects on mycobacterium tuberculosis suggest safe new adjuvant therapies for tuberculosis. Journal of Infectious Diseases, 208 (11). pp. 1925-1927.

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Abstract

[Extract] To the editor — The report on the intrinsic antimycobacterial activity of ibuprofen and low-dose aspirin in a novel murine tuberculosis model is fascinating and of relevance in the field. The paired advances of reporting new drug targets and further describing a readily reproducible model using commercially available C3HeB/FeJ mice is exciting. The authors have chosen not to describe further work on mechanisms of the nonsteroidal antiinflammatory drug (NSAID) effects in their preliminary report, but the accompanying editorial considers the antiinflammatory role of these cyclooxygenase inhibitors, revolving around prostaglandin (particularly PGE2) inhibition and consequent immune mediator cellular effects.

Item ID: 39749
Item Type: Article (Commentary)
ISSN: 1537-6613
Date Deposited: 08 Oct 2015 02:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 40%
16 STUDIES IN HUMAN SOCIETY > 1605 Policy and Administration > 160508 Health Policy @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 60%
92 HEALTH > 9203 Indigenous Health > 920309 Pacific Peoples Health - Health System Performance (incl. Effectiveness of Interventions) @ 20%
92 HEALTH > 9202 Health and Support Services > 920207 Health Policy Evaluation @ 20%
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