Strontium: friend or foe of bone formation? Commentary on "Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mousemarrow cultures"

Xie, H., and Ye, Q. (2015) Strontium: friend or foe of bone formation? Commentary on "Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mousemarrow cultures". Osteoporosis International, 26 (8). pp. 2213-2214.

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Abstract

[Extract] Dear Editor, In a recent issue of Osteoporosis International, we read with great interest the article by Wornham et al. detailing that Sr2+ acts as a global inhibitor of bone cell function, with particularly marked effects on mineralization. However, this finding contradicts with published studies which showed Sr^2+ is a promoter for bone formation. Clearly, the authors neglected the fact that Sr^2+ concentrations in biological microenvironment play essential roles in bone formation.

Item ID: 39282
Item Type: Article (Commentary)
ISSN: 1433-2965
Additional Information:

Commentary on Wornham D.P., Hajjawi M.O., Orriss I.R., Arnett T.R. (2014) Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mousemarrow cultures. Osteoporosis International 25:2477–2484. DOI:10.1007/s00198-014-2791-5.

Date Deposited: 16 Sep 2015 02:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 60%
09 ENGINEERING > 0903 Biomedical Engineering > 090302 Biomechanical Engineering @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 100%
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