Is there a new target in the renin-angiotensin system for aortic aneurysm therapy?

Golledge, Jonathan (2013) Is there a new target in the renin-angiotensin system for aortic aneurysm therapy? Arteriosclerosis, Thrombosis and Vascular Biology, 33 (7). pp. 1456-1457.

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[Extract] Aortic aneurysm and aortic dissection are important causes of mortality, which are principally managed by surgical interventions.The absence of specific medications which can limit the complications of these important aortic pathologies has stimulated an intense interest in studying the mechanisms underlying these diseases. A major focus of these studies has been the renin–angiotensin system. Angiotensin II has been linked to aortic aneurysm and dissection on the basis of evidence from a range of studies. In >100 studies in specific mice species (eg, apolipoprotein E–deficient mice), it has been shown that angiotensin II infusion stimulates aortic aneurysm and dissection formation and rupture. Such angiotensin II–induced aneurysms have some features typically found in human abdominal aortic aneurysms, including upregulation of proinflammatory cytokines and matrix metalloproteinases and marked influx of inflammatory cells. The concentration of a variety of angiotensin II–producing enzymes, including angiotensin-converting enzyme (ACE) and chymase, is increased in biopsies of human aortic aneurysm. In some rodent model studies inhibiting angiotensin II using angiotensin type 1 receptor (ATR1) blockers or ACE inhibitors has been successful in limiting aneurysm development or progression. Genetic polymorphisms in the ATR1 have been associated with human aortic aneurysm. On the basis of these and other data, several trials are underway to assess the efficacy of ATR1 blockers and ACE inhibitors in limiting progression of thoracic and abdominal aortic aneurysm.

Item ID: 39268
Item Type: Article (Editorial)
ISSN: 1524-4636
Keywords: editorials; aneurysm; dissection; mineralocorticoid
Date Deposited: 19 Nov 2015 04:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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