Marshman, Laurence A.G., Morice, Alyn H., and Thompson, Justine S. (1998) Increased efficacy of Sodium nitroprusside in middle cerebral arteries following acute subarachnoid haemorrhage. Journal of Neurosurgical Anesthesiology, 10 (3). pp. 171-177.

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Abstract

Sodium nitroprusside (SNP) is commonly used for controlled systemic hypotension during aneurysm surgery after acute subarachnoid hemorrhage (SAH). Few experimental studies have assessed cerebrovascular responsiveness to SNP acutely after a representative SAH (i.e., following arterial rupture within the subarachnoid space). Instead, most studies have focused on delayed reactivity after slow injections of unpressurised blood throughout several days in the authors' study, SAH was created by endovascular rupture in spontaneously breathing rats under urethane anesthesia without craniotomy. After 3 hours, proximal middle cerebral arteries (MCAs) were harvest and mounted as ring preparations in vitro. After preconstriction with 30 mM prostaglandin F2a, concentration-response curves were generated to express SNP's sequential relaxation of preconstricted tone. The effective concentration of SNP for 50% relaxation was significantly lower after SAH (p < 0.001) with SNP. The results of this study suggest that SNP is a potent and efficacious dilator of MCAs in the hours immediately after acute SAH.

Item ID:	39081
Item Type:	Article (Research - C1)
ISSN:	1537-1921
Keywords:	nitroprusside; subarachnoid hemorrhage; cerebral vessels
Date Deposited:	20 Oct 2015 03:42
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 50%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 50%
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