Bourne, Gregory T., Nielson, Jonathon L., Coughlan, Justin F., Darwen, Paul, Campitelli, Marc R., Horton, Douglas A., Rhümann, Andreas, Love, Stephen G., Tran, Tran T., and Smythe, Mark L. (2005) A convenient method for synthesis of cyclic peptide libraries. In: Howl, John, (ed.) Peptide Synthesis and Applications. Methods in Molecular Biology, 298 (298). Humana Press, Totowa, New Jersey, pp. 151-166.

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Abstract

Cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. Owing to the robustness of amide bond chemistry, the ability to explore extensive chemical diversity by incorporation of unnatural and natural amino acids, and the ability to explore conformational diversity, through the incorporation of various constraints, arrays of cyclic peptides can be tailored to broadly sample chemical diversity. We describe the combination of a safety catch linker with a directed-sorted procedure for the synthesis of large arrays of diverse cyclic peptides for high-throughput screening.

Item ID:	38933
Item Type:	Book Chapter (Research - B1)
ISBN:	1-59259-877-3
ISSN:	1064-3745
Keywords:	cyclicpeptides, combinatorial synthesis, safety-catch linker
Date Deposited:	12 Sep 2017 00:00
FoR Codes:	03 CHEMICAL SCIENCES > 0307 Theoretical and Computational Chemistry > 030799 Theoretical and Computational Chemistry not elsewhere classified @ 30% 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 60% 08 INFORMATION AND COMPUTING SCIENCES > 0801 Artificial Intelligence and Image Processing > 080108 Neural, Evolutionary and Fuzzy Computation @ 10%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 80% 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 20%
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