Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature

Tonoli, Cajsa, Heyman, Elsa, Roelands, Bart, Pattyn, Nathalie, Buyse, Luk, Piacentini, Maria Francesca, Berthoin, Serge, and Meeusen, Romain (2014) Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature. Journal of Diabetes, 6 (6). pp. 499-513.

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Abstract

Background: Type 1 diabetes (T1D) can have a significant impact on brain structure and function, which is referred to as T1D-associated cognitive decline (T1DACD). Diabetes duration, early onset disease, and diabetes-associated complications are all proposed as factors contributing to T1DACD. However, there have been no comparisons in T1DACD between children and adults with T1D. To obtain a better insight into the occurrence and effects of T1DACD in T1D, the aim of the present meta-analysis was to investigate differences between children and adults and to analyse factors contributing T1DACD.

Methods: Two electronic databases were consulted: PubMed and ISI Web of Knowledge. Literature published up until the end of 2013 was included in the analysis. Effect sizes (Cohen's d), which are standardized differences between experimental and control groups, were calculated.

Results: There was a small to modest decrease in cognitive performance in T1D patients compared with non-diabetic controls. Children with T1D performed worse while testing for executive function, full intelligence quotient (IQ), and motor speed, whereas adults with T1D performed worse while testing the full, verbal and performance IQ, part of the executive function, memory, spatial memory, and motor speed. Episodes of severe hypoglycemia, chronic hyperglycemia, and age of onset can be significant factors influencing cognitive function in T1D.

Conclusions: The findings in the literature suggest that T1DACD is more severe in adults than children, indicating that age and diabetes duration contribute to this T1DACD.

Item ID: 38766
Item Type: Article (Research - C1)
ISSN: 1753-0407
Keywords: diabetes; diabetes-associated cognitive decline; hyperglycemia; hypoglycemia
Funders: Vrije Universiteit Brussel, Research Fund of Flanders (FWO), University of Lille Nord de France
Projects and Grants: Vrije Universiteit Brussel (OZR2096BOF)
Date Deposited: 14 May 2015 03:24
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 36%
11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 33%
11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 33%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 50%
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