Unsuspected colchicine overdose in a female patient presenting as an acute abdomen

Blackham, R.E., Little, M., Baker, S., Augustson, B.M., and Macquillan, G.C. (2007) Unsuspected colchicine overdose in a female patient presenting as an acute abdomen. Anaesthesia and Intensive Care, 35 (3). pp. 437-439.

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We report a case of multi-system organ failure as a result of unsuspected colchicine overdose in a patient with known gout and bulimia nervosa. The patient had initially presented with mild gastrointestinal symptoms with rapid progression to fulminant hepatic failure and multiple organ dysfunction before the causative agent was identified. The patient survived with aggressive intensive care support and ongoing medical treatment. Physicians should be aware of the risk assessment based on the ingested dose and that the clinical presentation of colchicine in toxic doses may be non-specific with high potential for severe morbidity or death and that survival may occur despite multiple organ failure requiring aggressive support.

Item ID: 38631
Item Type: Article (Case Study)
ISSN: 1448-0271
Keywords: colchicine, overdose, toxicology, poisoning, hepatic failure
Date Deposited: 16 Jul 2015 03:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl Clinical Toxicology) @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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