Influence of living cells (L929) on the biodegradation of magnesium–calcium alloy

Kannan, M. Bobby, Yamamoto, A., and Khakbaz, Hadis (2015) Influence of living cells (L929) on the biodegradation of magnesium–calcium alloy. Colloids and Surfaces B: Biointerfaces, 126. pp. 603-606.

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Abstract

In this study, the influence of living cells (L929) on the in vitro degradation behaviour of a magnesium–calcium alloy was investigated using an electrochemical technique in the Eagle's minimum essential medium (EMEM) with 10% foetal bovine serum (FBS) under 5% CO2 atmosphere. The degradation of the alloy increased significantly in the medium containing the cells as compared to that without cells. Post-degradation analysis revealed localized degradation in the vicinity of the cells. It is suggested that the cell metabolic activity has induced local pH drop and as a result increased the alloy degradation.

Item ID: 38576
Item Type: Article (Research - C1)
ISSN: 1873-4367
Keywords: magnesium; biomaterials; degradation; L929 cells
Funders: National Institute for Materials Science (NIMS), Japan Society for Promotion of Science (JSPS)
Projects and Grants: JSPS Grant number 26282151
Date Deposited: 26 Jun 2015 04:27
FoR Codes: 09 ENGINEERING > 0903 Biomedical Engineering > 090301 Biomaterials @ 100%
SEO Codes: 86 MANUFACTURING > 8611 Basic Metal Products (incl. Smelting, Rolling, Drawing and Extruding) > 861199 Basic Metal Products (incl. Smelting, Rolling, Drawing and Extruding) not elsewhere classified @ 100%
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