Optimization of the rodent model of polymicrobial sepsis

Griffin, Maddison, Letson, Hayley L., and Dobson, Geoffrey P. (2014) Optimization of the rodent model of polymicrobial sepsis. International Immunopharmacology, 19 (2). p. 405.

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[Extract] Severe sepsis activates the systemic inflammatory and coagulation systems and is a leading cause of global morbidity and mortality claiming over 8 million lives every year [1]. New therapies are urgently required to slow or alleviate the progression of the infection. We congratulate Wang and colleagues [2] on their contribution to seek improved drug therapies to treat sepsis. They showed that the serine protease inhibitor, Ulinastatin, may be an effective candidate to increase survival, attenuate inflammation and prevent systemic disorder and organ dysfunction following sepsis.

Item ID: 38543
Item Type: Article (Short Note)
ISSN: 1878-1705
Keywords: cecal puncture; optimization; rat model; sepsis
Date Deposited: 27 Apr 2015 00:29
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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