Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

Williams, Natasha L., Morris, Jodie L., Rush, Catherine M., and Ketheesan, Natkunam (2015) Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei. Microbes and Infection, 17 (4). pp. 311-316.

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Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.

Item ID: 38346
Item Type: Article (Research - C1)
ISSN: 1769-714X
Keywords: Burkholderia pseudomallei; Melioidosis; Dendritic cells; Interferon-alpha; Interferon-beta
Funders: Far North Queensland Hospital Foundation, James Cook University
Date Deposited: 10 Jun 2015 02:17
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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