Ruthenium complexes as antimicrobial agents

Li, Fangfei, Collins, J. Grant, and Keene, F. Richard (2015) Ruthenium complexes as antimicrobial agents. Chemical Society Reviews, 44. pp. 2529-2542.

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Abstract

One of the major advances in medical science has been the development of antimicrobials; however, a consequence of their widespread use has been the emergence of drug-resistant populations of microorganisms. There is clearly a need for the development of new antimicrobials – but more importantly, there is the need for the development of new classes of antimicrobials, rather than drugs based upon analogues of known scaffolds. Due to the success of the platinum anticancer agents, there has been considerable interest in the development of therapeutic agents based upon other transition metals – and in particular ruthenium(II/III) complexes, due to their well known interaction with DNA. There have been many studies of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukaryotic cells over the last decade. However, only very recently has there been significant interest in their antimicrobial properties. This review highlights the types of ruthenium complexes that have exhibited significant antimicrobial activity and discusses the relationship between chemical structure and biological processing – including site(s) of intracellular accumulation – of the ruthenium complexes in both bacterial and eukaryotic cells.

Item ID: 38252
Item Type: Article (Research - C1)
ISSN: 1460-4744
Keywords: antimicrobial; ruthenium; antibacterial
Additional Information:

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Date Deposited: 23 Apr 2015 05:27
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110801 Medical Bacteriology @ 40%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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