Almeida, O.P., Yeap, B.B., Hankey, G.J., Golledge, J., and Flicker, L. (2014) HDL cholesterol and the risk of depression over 5 years. Molecular Psychiatry, 19. pp. 637-638.

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Abstract

[Extract] Abnormalities in lipid metabolism have been associated with prevalent depression and suicide behaviour, with low concentration of plasma high-density lipoprotein (HDL) cholesterol being consistently linked to depression.1 As most studies that have investigated this association have had a cross-sectional design, reverse causality and confounding could plausibly explain their findings. This prospective study sought to determine whether the plasma concentration of lipids, and more specifically of HDL cholesterol, was associated with increased risk of depression 5 years later, independent of cardiovascular diseases, diabetes, body mass, lifestyle factors and history of past depression.

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