Neuroprotective therapies for Alzheimer's disease

Huber, Anke, Stuchbury, Grant, Bürkle, Alex, Burnell, Jim, and Münch, Gerald (2006) Neuroprotective therapies for Alzheimer's disease. Current Pharmaceutical Design, 12 (6). pp. 705-717.

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Abstract

One of the major age-related damaging agents are reactive oxygen species (ROS). The brain is more vulnerable to oxidative stress than other organs as concomitant low activity and capacity of antioxidative protection systems allow for increased exposure of target molecules to ROS. Since neurons are postmitotic cells, they have to live with cellular damage accumulated over many decades. Increased levels of ROS (also termed "oxidative stress"), produced by normal mitochondrial activity, inflammation and excess glutamate levels, are proposed to accelerate neurodegenerative processes characteristic of Alzheimer's disease. This review presents evidence of the importance of oxidative stress in the pathogenesis of these diseases and explains the nature of different types of ROS mediating neuronal damage. Furthermore, the potential beneficial effects of neuroprotective treatments, including antioxidants and anti - glutamatergic drugs are discussed.

Item ID: 3725
Item Type: Article (Research - C1)
ISSN: 1873-4286
Keywords: Alzheimer's Disease; antioxidants; NMDA receptors
Date Deposited: 24 Nov 2009 04:18
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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