Extreme hypertriglyceridemia managed with insulin

Thuzar, Moe, Shenoy, Vasant V., Malabu, Usman H., Schrale, Ryan, and Sangla, Kunwarjit S. (2014) Extreme hypertriglyceridemia managed with insulin. Journal of Clinical Lipidology, 8 (6). pp. 630-634.

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Abstract

Extreme hypertriglyceridemia can lead to acute pancreatitis and rapid lowering of serum triglycerides (TG) is necessary for preventing such life-threatening complications. However, there is no established consensus on the acute management of extreme hypertriglyceridemia. We retrospectively reviewed 10 cases of extreme hypertriglyceridemia with mean serum TG on presentation of 101.5 ± 23.4 mmol/L (8982 ± 2070 mg/dL) managed with insulin. Serum TG decreased by 87 ± 4% in 24 hours in those patients managed with intravenous insulin and fasting and 40 ± 8.4% in those managed with intravenous insulin alone (P = .0003). The clinical course was uncomplicated in all except 1 patient who subsequently developed a pancreatic pseudocyst. Thus, combination of intravenous insulin with fasting appears to be an effective, simple, and safe treatment strategy in immediate management of extreme hypertriglyceridemia.

Item ID: 36970
Item Type: Article (Research - C1)
ISSN: 1876-4789
Keywords: hypertriglyceridemia, insulin, diabetes, dyslipidemia, pancreatitis
Date Deposited: 27 May 2015 01:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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