Haleagrahara, Nagaraja, Chakravarthi, Srikumar, Bangra Kulur, Anupama, and Yee, Tan Mun (2014) Plant flavone apigenin protects against cyclosporine-induced histological and biochemical changes in the kidney in rats. Biomedicine and Preventive Nutrition, 4 (4). pp. 589-593.

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Abstract

Cyclosporine (CsA) is an immunosuppressant drug universally used for the prevention of transplant rejection and also for the treatment of autoimmune diseases. Use of cyclosporine has been limited by its side effects such as hypertension and renal damage. Antioxidants are known to protect free radical induced damage of tissues during drug toxicity. The aim of this study was to test the role of plant flavone apigenin against cyclosporine-induced nephrotoxicity. Adult male Sprague Dawley rats were randomly divided into control, cyclosporine alone, and cyclosporine with apigenin (10, 15 and 20 mg/kg). Cyclosporine treatment was continued for 21 days to induce nephrotoxicity. From the blood samples, urea, uric acid, total antioxidants and lipid hydroperoxide assays were done. There was a significant renal damage with cyclosporine alone treatment. Blood urea nitrogen, urea, uric acid and lipid hydroperoxides were significantly elevated whereas there was a significant decrease in the total antioxidant levels. Treatment with apigenin significantly reduced the lipid hydroperoxides and increased the total antioxidant levels. Concurrent apigenin treatment significantly reduced the histopathological changes in the CsA treated groups. In conclusion, the study confirmed the role of oxidative stress in the pathogenesis of cyclosporine-induced nephrotoxicity and protective effects of flavone apigenin against free radical-induced renal damage.

Item ID:	36883
Item Type:	Article (Research - C1)
ISSN:	2210-5239
Keywords:	antioxidants; oxidative stress; nephrotoxicity; cyclosporine; apigenin; kidney
Date Deposited:	11 Feb 2015 04:16
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified @ 40% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110316 Pathology (excl Oral Pathology) @ 20% 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl Clinical Toxicology) @ 40%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920119 Urogenital System and Disorders @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 50%
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