A flow chemistry approach to norcantharidin analogues

Tarleton, Mark, Young, Kelly A., Unicomb, Elli, McCluskey, Siobhann N., Robertson, Mark J., Gordon, Christopher P., and McCluskey, Adam (2011) A flow chemistry approach to norcantharidin analogues. Letters In Drug Design and Discovery, 8 (6). pp. 568-574.

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Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube™ flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.

Item ID: 36837
Item Type: Article (Research - C1)
ISSN: 1875-628X
Keywords: cantharidin, norcantharidin, flow hydrogenation, flow chemistry, protein phosphatase inhibition
Funders: Australian Research Council (ARC), Australian Cancer Research Foundation, Ramaciotti Foundations
Date Deposited: 10 Dec 2014 07:31
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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