Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

Bremner, John B., Keller, Paul A., Pyne, Stephen G., Boyle, Timothy P., Brkic, Zinka, David, Dorothy M., Robertson, Mark, Somphol, Kittiya, Baylis, Dean, Coates, Jonathan A., Deadman, John, Jeevarajah, Darshini, and Rhodes, David I. (2010) Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1. Bioorganic & Medicinal Chemistry, 18 (7). pp. 2611-2620.

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An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9–3.9 µg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 µg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2 µg/mL against vancomycin-resistant strains of enterococci (VRE).

Item ID: 36825
Item Type: Article (Research - C1)
ISSN: 1464-3391
Keywords: tripeptoids, cationic, antibacterial, binaphthyl
Funders: Amrad Operations Pty Ltd, Avexa Ltd, University of Wollongong, National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC (303415 and 404528)
Date Deposited: 10 Dec 2014 07:31
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 50%
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