Can schistosomiasis really be consigned to history without a vaccine?

Bethony, Jeffrey M., Diemert, David J., Oliveira, Sergio Costa, and Loukas, Alex (2008) Can schistosomiasis really be consigned to history without a vaccine? Vaccine, 26 (27-28). pp. 3373-3376.

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Recently, considerable enthusiasm has been expressed for expanding and combining control efforts for neglected tropical diseases (NTDs). While these efforts are laudable, the drugs in question require repeated mass administration for indefinite periods of time, and their use to achieve eradication is fraught with challenges. Mass drug administration is unlikely to be effective in isolation, and should not proceed without concurrent control methods, such as vaccines. Schistosomiasis is one of the most important NTDs, and one whose effective control is unlikely in the absence of improved sanitation and a vaccine. Recent advances in biotechnologies have enhanced antigen discovery and new molecules that show promise as recombinant vaccines are being reported. Funding bodies supporting research into the control of schistosomiasis should invest not only in mass drug administration but also in the development of new control strategies, including the development of vaccines.

Item ID: 36731
Item Type: Article (Commentary)
ISSN: 1873-2518
Keywords: schistosoma; vaccine; praziquantel
Funders: National Health and Medical Research Council of Australia (NHMRC), National Institutes of Health, Funding Authority for Studies and Projects, Brazil (FINEP), FAPEMIG, CNPq
Date Deposited: 10 Dec 2014 03:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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