Golledge, Jonathan, Jones, Leonie, Oliver, Lisa, Quigley, Francis, and Karan, Mirko (2006) Folic acid, Vitamin B12, MTHFR genotypes and plasma homocysteine. Clinical Chemistry , 52 (6). pp. 1205-1206.

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Abstract

[Extract] We read with interest the article by Pastore et al. (1), who demonstrated that the effect of folate and vitamin B12 treatment in reducing total plasma homocysteine (tHcy) concentration is dependent on methylenetetrahydrofolate reductase (MTHFR) genotype in patients with end-stage renal failure. Their findings may partially explain the difficulty in demonstrating a benefit of vitamin supplementation in reducing cardiovascular end-point, as treatment may have to be tailored to subgroups of patients such as those with the MTHFR T allele (2)(3). Although tHcy concentrations are much lower in individuals with normal renal function, they still predict subsequent cardiovascular events (4).

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