Conservative management of oral submucous fibrosis

Ariyawardana, Anura, Nawagamuwa, Tharanga, Ranasinghe, Ajith W., Sitheeque, Mohamed, and Vitanaarachchi, Nishwanthi (2005) Conservative management of oral submucous fibrosis. Asian Journal of Oral and Maxillofacial Surgery, 17 (1). pp. 26-30.

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Objective: To assess the effectiveness of intralesional injection of methylprednisolone and habit control in the management of oral submucous fibrosis.

Patients and Methods: The study included 43 patients who attended the Department of Oral Medicine and Periodontology, University of Peradeniya, Peradeniya, Sri Lanka, from January 2001 to December 2003. The patients were divided into 3 groups according to maximum mouth opening of ≥20 mm (group A), maximum mouth opening from 11 to 19 mm (group B), and maximum mouth opening of ≤10 mm (group C). Bilateral submucosal injection of methylprednisolone 20 mg/0.5 mL was given to predetermined areas of the buccal mucosa once a month for 5 consecutive months. Maximum unaided mouth opening was measured using the same measuring device after each injection. All patients were informed about the causal relationship of their betel chewing habit to oral submucous fibrosis and the risks if they continued to chew betel. They were instructed to stop betel chewing, smoking, and drinking alcohol.

Results: After 6 months of follow-up, 37 patients (86.0%) showed significant improvement (z = −5.283; p < 0.05) in mouth opening. Thirty three of 38 patients (86.8%) in group A showed improvement at 6 months' follow-up (z = −5.003; p < 0.05). Although 3 of 4 patients in group B experienced an improvement after 6 months, the difference was not statistically significant.

Conclusion: The results strongly suggest that intralesional injection of methylprednisolone to the buccal mucosa for treatment of oral submucous fibrosis significantly improves mouth opening.

Item ID: 36579
Item Type: Article (Research - C1)
ISSN: 0915-6992
Keywords: areca; cell transformation; neoplastic; methylprednisolone; oral submucous fibrosis
Date Deposited: 16 Oct 2015 03:13
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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